Methods: Potential radiosensitizing effects of the HSP90 inhibitor Onalespib were studied in XTT and clonogenic survival assays as well as in tumor-mimicking multicellular spheroid models. Further, ...

The peak-to-valley dose ratio (PVDR, used to characterize an MRT field) of this set-up was measured as 8.9. Using a clonogenic assay to measure cell survival, the team observed that synchrotron-based ...

Lipofectamine 2000 was used for cell transfection. Cells (3000/well) were inoculated on 96-well plates for the MTT assay, and absorbance was recorded at various time intervals to gauge cell viability.

Design In vitro response to APR-246 was assessed using clonogenic survival, cell cycle and apoptosis assays. Ectopic expression, gene knockdown and CRISPR/Cas9-mediated knockout studies of mutant p53 ...

Clonogenic survival of pMMR colorectal cancer cell lines after IR (4 Gy ... acute weight loss (% from baseline), and H) FITC/Dextran permeability assay. Tissue samples were graded for Radiation Injury ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Aneuploidy is prevalent in cancer and ...

1Department of Radiation Oncology, Inselspital Bern University Hospital, Bern, Switzerland. 2Department for BioMedical Research, Radiation Oncology, University of Bern, Bern, Switzerland. 3Graduate ...

Faculty of Chemistry, Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, 1090 Vienna, Austria Vienna Doctoral School in Chemistry (DoSChem), University of Vienna, Waehringer ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Breast cancer is a leading cause of mortality ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...