MBT-C101 is a selective, potentially first-in-class potent HSP90 chaperone-mediated degrader of PI3Kα, for the treatment of breast cancer. It was developed by Magicbullet Therapeutics Inc. using the ...

In this process, the autophagic cargo receptors SQSTM1/p62 and NBR1 drive cargo condensation, while TAX1BP1, which binds to NBR1, recruits the autophagy machinery to facilitate autophagosome ...

Halloween Horror Nights doesn’t have an age limit, although Universal does not recommend it for children under 13. The Universal Orlando Resort FAQ page also notes the theme parks don’t have a ...

School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China ...

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Damaged or superfluous proteins and other components inside a cell are broken down in a process called autophagy. Aging research has established that autophagy pathways become less active with age ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Lysosomal damage induces stress granule (SG) ...