p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...
Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...
CDCA7 binds to the hemimethylation site in the major groove of nucleosomal DNA without base-flipping. R274 confers preferential binding of CDCA7 to a hemimethylated CpG. The side chain of Q275 is ...
While it has been known that mutations in the CDCA7 gene cause ICF syndrome, little was known about the gene's molecular function. Now Rockefeller University's Funabiki lab, in close collaboration ...
The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.
The findings were recently published in Communications Chemistry. p53 is central to the body's defense against cancer, tasked with regulating the cell cycle and triggering the death of damaged ...