Intellia Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Intellia's technology platform specializes in Clustered Regularly Interspaced Short ...

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Researchers have identified an ancient RNA-guided system that can target DNA, potentially expanding the genome-editing toolbox.

CRISPR-Cas9 genome editing exploits the CRISPR-Cas ... uses an amphiphilic peptide reagent to mediate intracellular delivery of CRISPR enzymes for high-efficiency editing of stimulated immune ...

to assist Cas9, a DNA-cleaving enzyme, to reach its genomic target DNAs. 4 CRISPR-Cas9 is often called a molecular scissor made of RNA and enzymes. Even though this technology holds immense ...

Armed with new proof-of-concept data showing that its in vivo base-editing therapy BEAM-302 can correct the gene mutation in ...

A vast search of natural diversity has led scientists at MIT's McGovern Institute and the Broad Institute of MIT and Harvard ...

They also add further insight into why it is advantageous to design engineered guideRNAs, as opposed to engineered Cas9 enzymes, to improve the modularity of the system in the future. The manuscript ...

The main difficulty is the bulky nature of the components of CRISPR, particularly the 1300 amino acid Cas9 enzyme employed to cut the DNA. This amount of amino acids translates to proteins with a ...