Beta3-adrenergic receptors (β3AR) have emerged as significant players in the management of heart failure (HF) and cardiac function. Traditionally, beta-adrenergic receptors have been associated ...

Given that most pressor agents (sympathetic agonists, endothelin, or angiotensin-II) also stimulate contractility by directly activating their respective cardiac receptors and augment preload (by ...

This review examines the cardiovascular risks associated with cannabis, revealing its potential to cause severe heart health ...

Clinicians may one day be able to treat immune checkpoint inhibitor-related myocarditis without disrupting cancer therapy, findings from a cellular investigation showed.Individuals who die of immune ...

"These new structural details will be of interest to drug developers who want to target GC-A and related receptors to treat heart disease and other conditions," said study senior author Xin-Yun ...

The classification of drugs have been around since 1964 after Sir James Black discovered how they can assist people with ...

The latter promotes phenotypic changes in these cells that are consistent with cardiac remodeling. The effects of ET are mediated through interaction with two classes of cell surface receptors.

The addition of β-adrenergic receptor antagonists to a medical regimen for heart failure that includes angiotensin-converting enzyme (ACE) inhibitors as background therapy has been associated ...

G protein-coupled receptor kinase 2 (GRK2) is involved in heart failure (HF) progression and its upregulation contributes to adverse cardiac remodeling and dysfunction. In mouse models of HF, ...