A new CRISPR-Cas toolkit, dubbed "pAblo·pCasso," is set to transform the landscape of bacterial genome editing, offering unprecedented precision and flexibility in genetic engineering.

So why do we call it CRISPR? Cas proteins are used by bacteria to destroy viral DNA. They add bits of viral DNA to their own genome to guide the Cas proteins, and the odd patterns of these bits of ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

6, 2024 — The CRISPR ... that bacteria use to respond to viral ... Aug. 9, 2024 — A 'loopy' discovery in bacteria is raising fundamental questions about the makeup of our own genome -- and ...

as viruses try to inject their DNA into the bacterial genome and bacteria devise cunning methods (e.g. CRISPR) to defend ...

Named Science Magazine’s 2015 Breakthrough of the Year, the CRISPR/Cas9 genome editing system has taken the biotechnology world by storm. CRISPR/Cas9—a technology derived from a naturally occurring ...

It has emerged as a powerful tool for genome engineering, with applications spanning from basic research to biotechnology and medicine. Bacteria and archaea possess adaptive immunity against foreign ...

This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The ...

Various types of endonucleases – enzymes that can cut DNA – were already known before CRISPR-Cas9. The discovery of restriction enzymes in the early 1970s heralded a new age in molecular biology.

CRISPR-based gene-editing tools are being developed to correct specific defective sections of the genome to cure inherited genetic diseases, with some applications already in clinical trials. However, ...

Using CRISPR technology that targets RNA instead of DNA, researchers at New York University and the New York Genome Center searched across the genome and found nearly 800 noncoding RNAs important ...