but unexpected expression patterns of cre transgenes, variability of recombination efficiency depending on the target gene and potential toxicity of Cre recombinase represent serious challenges ...

This important study reveals a critical role of the transcription factor NR2F2 in mouse fetal Leydig cell (FLC) differentiation. With elegantly carried out experiments, the authors provide compelling ...

Miriam Wheeler, head of the global real estate financing group at Goldman Sachs (GS), said she doesn’t share concerns others in the CRE industry have voiced about Trump’s economic proposals such as ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The NLRP3 inflammasome plays a pivotal role in ...

Connecting decision makers to a dynamic network of information, people and ideas, Bloomberg quickly and accurately delivers business and financial information, news and insight around the world ...

This valuable study shows that eliminating a large portion of the principal neurons in the mammalian olfactory bulb does not affect the initial establishment of the circuit but has an impact on its ...

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23 Cre was activated by intraperitoneal injections of tamoxifen at a dose of 1 mg/d for 5 subsequent days at the age of 4 weeks. Control animals were treated with corn oil, the solvent of tamoxifen.

Therefore, single-cell synaptome mapping can gain a deeper insight into the synaptic and cellular mechanisms underlying circuit remodeling during the critical period. Cre-loxP-mediated conditional KI ...