Sage Therapeutics has been working in the area of steroid-derived compounds that affect CNS receptor signaling.

This not only makes eradication of the virus very difficult but also increases the risk of viral mutation, leading to drug resistance and treatment failure. One of these sites is the CNS.

A broad range of nanomedicines is being developed to improve drug delivery for CNS disorders. The structure of the blood-brain barrier (BBB), the presence of efflux pumps and the expression of ...

Most drug discovery efforts aimed at type 2 diabetes target insulin action in peripheral tissues (muscle, fat and liver). Recently, data have emerged that suggest the central nervous system (CNS ...

This makes drug development for CNS diseases difficult, as traditional preclinical models are unable to routinely identify molecules that would have a high probability of success in the clinic.

Benzodiazepines are a class of drugs (commonly referred to as “benzos”) prescribed to treat anxiety, panic disorder, seizures ...