1UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California. 2Division of Hematology and Oncology, Department of Medicine, University of California San Francisco, San Francisco, ...

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In two new papers, both published in Cell Reports Medicine, they do both, describing the mechanisms of how alterations in the CDK12 gene drive prostate cancer development and reporting on a promising ...

Disease Target Structure Research Center, Division of Biomedical Research, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea Department of Proteome ...

Similar to how inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6 ... Robinson DR, Chinnaiyan AM. Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer. Cell.

Many investigational drugs designed to target CDK12 also inhibit the structurally ... Recursion entered a definitive agreement to combine with U.K.-based Exscientia. According to Recursion ...

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Until now there hasn’t been a selective therapeutic agent to exploit this observation and so I am extremely excited to see Circle Pharma’s cyclin A/B RxL inhibitor move into the clinic." ...