CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous ...
研究者表示,Asxl1能破坏其赋予T细胞优越的长期治疗潜力,而这或许是未来科学家们设计基于T细胞的免疫疗法的一种非常有希望的策略。 免疫疗法能利用患者自身的免疫系统来治疗疾病,其在一些癌症患者身上展现出了一定的希望,但对于大多数患者而言却并不奏效。近日,一篇发表在国际杂志Science上题为“Epigenetic regulators of clonal hematopoiesis control ...
26 in Nature Immunology, the researchers discovered that activating a metabolic pathway called the pentose phosphate pathway makes antitumor CD8 T cells more likely to stay in an immature ...
"Having more of these precursors enables a more sustained supply of active cytotoxic CD8 + T cells for attacking tumors," said Dr. Mittal, who is also a member of the Sandra and Edward Meyer ...