Obtaining Brimstone can make a world of difference ... on the map by combining the effects of all other mapping items. The Binding Of Isaac offers lots of characters for players to use in their ...

The D6 allows players to re-roll items, unlocking it by defeating boss Isaac with ??? Azazel, unlocked by 3 deals with the devil, offers powerful Brimstone tears and flight. Unlock Mom's Knife by ...