Study objectives: Prior to the availability of the oral endothelin antagonist bosentan, most patients with pulmonary arterial hypertension (PAH) were treated with continuously infused prostacyclins.

There have been no published studies to date demonstrating safe and effective transition to oral bosentan in patients with persisting significant PAH previously receiving continuous prostacyclin ...

Over the past 10 years, a number of drugs have been used to treat pulmonary hypertension in scleroderma, including prostacyclin-like drugs (epoprostenol, iloprost), endothelin receptor antagonists ...

Background Vasoreactivity testing is recommended in the management of pulmonary arterial hypertension (PAH), but its clinical relevance in congenital heart disease (CHD)-associated PAH has not been ...

10 Oral therapies for PAH such as endothelin receptor antagonists (eg, bosentan) and phosphodiesterase inhibitors (eg, sildenafil) may improve symptoms and the quality of life of PAH patients, but it ...

Right heart catheterization confirmed mixed pre- and post-capillary pulmonary hypertension, with mPAP of 53 mmHg, PVR 9.33WU and PCWP of 25 mmHg. She was started on bosentan and tadalafil, with ...

The company brought with it a group of medicines that treat pulmonary arterial hypertension – well-established blockbuster Tracleer (bosentan), and the more recently-approved Opsumit (macitentan ...

14 It is not used in children. Iloprost is a prostacyclin analogue which can be given by inhalation but small, tired children find it difficult to inhale an effective dose every 2 h. The drug is ...

The endothelium, which forms the inner lining of all blood vessels, is a highly selective barrier for blood constituents. Formation of gaps between endothelial cells (ECs), for instance during ...

The Young and the Restless spoilers reveal there is no new episode on Wednesday, January 1. So, what’s happening on Thursday, January 2, 2025? Fans will see Mariah Copeland (Camryn Grimes) react to ...

Learn how to use a range of prefixes to form and spell words. Suffixes and how to use them Learn how to use a range of suffixes to change the meaning of words. Using suffixes to show tenses Learn ...

Objectives To better understand the patient's perspective of pulmonary hypertension (PH), including the impact of living with PH, disease management and treatment. Design This qualitative ethnographic ...