Aims: To analyse the signalling pathway of butyrate induced apoptosis. Methods: Using Caco-2 cells we focused on the bcl family of proteins, mitochondrial pathway, and caspase signalling cascade ...

Apoptosis is an essential characteristic of cancer and its dysregular promotes tumor growth, clonal evolution, and treatment resistance. B-cell lymphoma-2 (BCL-2) protein family members are key to the ...

Figure 2: Inhibition of caspase 3, apoptosis (caspase ... distinct cellular stress pathways and signal that a stress has occurred through interactions with other BCL-2 family members.

Mechanistically, KPF treatment regulated the expression of autophagic proteins (upregulated LC3II, Beclin-1, Atg7 and Atg 5, and downregulated p62/SQSTM1), accompanied by inhibited renal apoptosis ...

BH3-only proteins and pharmacological BH3 mimetics competitively disrupt the inhibitory interaction between beclin-1 and BCL2 or BCL ... pathways can elicit both autophagy and apoptosis. Figure 2 ...

Peptide therapy enhances targeted medicine, utilizing specific peptides for effective treatment of cancer, metabolic disorders, and neurodegenerative diseases.

Kuick Research Report Highlights Ongoing Developments In Molecular Switches Application Therapeutic Targets & Drug Delivery ...

Deregulated apoptosis may also be the leading cause of cancer therapy ... as DED (caspase-8 and -10), and caspase recruitment domains (CARD) (caspase-1, -2, -4, -5, -9, -11 and -12), which allow for ...

The P/B ratio shows how a stock's market price compares to its book value. It helps gauge whether a stock is undervalued or overvalued relative to its net assets.

Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...

The biggest stories of the day delivered to your inbox.

This is a Pytorch implementation of the BCL paper: If you find this code useful, please consider citing our paper: @inproceedings{zhu2022balanced, title={Balanced Contrastive Learning for Long-Tailed ...