The advent of large-scale sequencing in both development and disease has identified large numbers of candidate genes that may be linked to important phenotypes. Validating the function of these ...

In this important study, the authors used a zebrafish model and scRNAseq analysis to show that a subset of keratinocytes within melanoma microenvironment highly up-regulate Twist and undergo ...

Erasca has streamlined its pipeline, now focusing on a phase 3 trial for Naporafenib targeting NRAS-mutant melanoma. Read ...

Pasithea Therapeutics today announced safety, tolerability, pharmacokinetic (PK) and preliminary efficacy data from the first 2 cohorts of patients (n=6) in its Phase 1 clinical trial of PAS-004, ...

On Thursday, Pasithea Therapeutics Corp. (NASDAQ:KTTA) announced safety, tolerability, pharmacokinetic (PK), and preliminary ...

By taking proteins down the cell’s own degradation pathway instead of the typical inhibition approach, TPD allows researchers to develop successful therapies that address previously undruggable ...

Apoptosis is an evolutionarily conserved cell death pathway that plays a crucial role in maintaining tissue homeostasis, orchestrating organismal development, and eliminating damaged cells.

Prostate cancer remains one of the most prevalent malignancies in men across the world. The American Cancer Society estimates 299,010 new cases and about 35,250 deaths from prostate cancer in the ...

The measures we have taken and continue to take will protect the integrity and sustainability of our migration pathways, reduce fraud and relieve pressures on the housing and health care sectors, ...

BRAF, PIK3CA, and AKT1 genes in cancers that are impacted by the RAS-RAF and PI3K signaling pathways. Those mutations are relevant for the selection and monitoring of therapies for colorectal, ...