BRAF, a member of a serine/threonine kinase protein family, serves as an immediate downstream effector of RAS in the MAPK signaling cascade, a signal transduction pathway that transmits mitogenic ...

Novartis' two-drug regimen of Tafinlar and Mekinist has been approved by the FDA as the first therapy for solid tumours that have a BRAF V600E mutation – regardless of where they occur in the body.

The child and humility; importance of forgiveness; marriage and divorce; rich young ruler; laborers in the vineyard; request of James and John. Then came Peter to him, and said, Lord, how oft shall my ...

At Seattle Children’s, a clinical standard work (CSW) pathway is a documented approach to the management and treatment of a particular population or clinical condition. The aim is to improve quality ...

The advent of large-scale sequencing in both development and disease has identified large numbers of candidate genes that may be linked to important phenotypes. Validating the function of these ...

In this important study, the authors used a zebrafish model and scRNAseq analysis to show that a subset of keratinocytes within melanoma microenvironment highly up-regulate Twist and undergo ...