Over the last 2 decades, significant progress has been made in our understanding of the genomics, tumor immune ...

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is ...

Targeted therapy revolutionized cancer treatment, with gene fusions leading the way when the FDA approved imatinib in 2001 to ...

Gene silencing describes the epigenetic regulation of a gene, at the level of transcription or translation, to prevent gene expression. Mechanisms include DNA methylation, histone modification and ...

10Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California. 11Crump Institute for Molecular Imaging, University of California, Los Angeles, Los ...

Several new studies appear to confirm the test's potential to prevent overtreatment of melanoma patients while identifying those at high risk.

撰写这篇国际专家共识的初衷源于一次肺癌会议上的深刻讨论，我们意识到尽管BRAF突变在多种肿瘤中普遍存在，但其检测与治疗策略却缺乏统一的 ...

(A) Sample sizes, ranging from 10% to 100% with 10% intervals (“gradient”), were used for 1000 permutations of survival analyses of all 15 cancer types Each matrix was divided into high and low ...

A new clinical trial highlights that spotting a genetic subtype of these ATC tumors can be key to designing treatment that greatly extends survival ATC patients with BRAF gene mutations lived a median ...

A new clinical trial highlights that spotting a genetic subtype of these ATC tumors can be key to designing treatment that greatly extends survival ATC patients with BRAF gene mutations lived a ...

This has been particularly evident with several of the recently developed kinase inhibitors that target oncogenic forms of EGFR, HER2, BCR–ABL, ALK, JAK2 and BRAF, where clinical activity has ...