Investigators from Duke University hypothesized that hirudin-like protease inhibitors could be generated by linking exosite-binding aptamers with small-molecule active site inhibitors, thus generating ...

However, the potency of aptamers is often limited as they do not directly inhibit the catalytic sites on their targeted proteases. The natural anticoagulant hirudin achieves potent activity by ...

Medications for PE fall into two categories: blood thinners (anticoagulants) and clot-dissolvers (thrombolytics). These two classes of medications serve completely different purposes ...

School of Rare Earth, University of Science and Technology of China, Hefei 230026, China ...