Investigators from Duke University hypothesized that hirudin-like protease inhibitors could be generated by linking exosite-binding aptamers with small-molecule active site inhibitors, thus generating ...

Another r-hirudin, desirudin ... and the initiation of an alternative anticoagulant. Because r-hirudins are effective agents and do not cross-react with HIT-associated antibodies, they are ...

However, the potency of aptamers is often limited as they do not directly inhibit the catalytic sites on their targeted proteases. The natural anticoagulant hirudin achieves potent activity by ...

A left atrial appendage (LAA) closure device provides long-term thromboembolic protection that is equivalent to direct oral anticoagulants after ablation for atrial fibrillation (AF), along with a ...

Medications for PE fall into two categories: blood thinners (anticoagulants) and clot-dissolvers (thrombolytics). These two classes of medications serve completely different purposes ...

• Adjust starting time of warfarin based on CrCl as follows: º CrCl ≥50mL/min: Start warfarin 3 days before discontinuing dabigatran º CrCl 30−50mL/min: Start warfarin 2 days before ...

He then discusses consensus recommendations on cardiopulmonary resuscitation (CPR). Finally, Dr. Eagle explores bleeding risk using nonsteroidal anti-inflammatory drugs (NSAIDs) with anticoagulants ...

Anticoagulants (blood thinners) may be prescribed to patients for the treatment or prevention of blood clots. Our clinics are also often referred to as "Coumadin clinic" or "Warfarin clinic." ...