【导读】肝细胞癌（HCC）是恶性程度极高的肿瘤之一，严重威胁着全球人类健康，其发病率每年都在上升。USP15 是去泛素化酶（USP）家族的一员，能够调节蛋白质泛素化，从而影响其稳定性，在许多癌症中表达失调，但其在肝细胞癌中的表达情况及调控机制尚不清楚 ...

Furthermore, we show that regulation of ULK1/adenosine monophosphate-activated protein kinase (AMPK) signalling pathway by mTOR may in part be responsible for regulating autophagy signalling and the ...

Explore how inhibiting myostatin can promote muscle mass in men, addressing sarcopenia, GLP-1 medication effects, and aging ...

Miraculous, divine intervention because of obedience to God. Abraham does not hesitate to sacrifice Isaac. But thou shalt go unto my country, and to my kindred, and take a wife unto my son Isaac. And ...

This study addresses fundamental questions surrounding otitis media effusion in Down syndrome, identifying DYRK1A as a key gene involved in the condition. The findings are compelling, highlighting ...

2025年1月8日，中国科学院脑科学与智能技术卓越创新中心（神经科学研究所）周海波研究组在 Nature 子刊 Nature Aging 上发表了题为：Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegeneration 的研究论文。 该研究通过多组学时间梯度测序发现，静息状态的 ...