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In summary, there is a clear discrepancy in therapeutically targeting the LDHA-mediated aerobic glycolysis in activated immune cells and other tissues. While inhibiting LDHA activity primarily ...

Metabolic alterations in cancer cells are numerous and include aerobic glycolysis, reduced oxidative phosphorylation and the increased generation of biosynthetic intermediates needed for cell ...

Experts clear up the confusion on lactic acid, the burning sensation you feel in your legs during hard efforts, how to ...

Low-intensity Zone 2 workouts may sound simple, but they can improve metabolic health, help regulate blood sugar, and enhance ...

代谢重编程是肿瘤的基本特征之一。肿瘤细胞即使在氧气充足的条件下仍优先通过糖酵解途径产生能量，这种现象被称为Warburg效应。研究表明结直肠癌是一种具有典型Warburg 效应的肿瘤，在其发生发展过程中，有氧糖酵解起着非常重要的作用，抑制Warburg 效应 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The mevalonate pathway produces essential ...

4 Institute of Legal Medicine and Core Facility Metabolomics, Medical University Innsbruck, Innsbruck, Austria Objective Nicotinamide phosphoribosyltransferase (NAMPT, also referred to as pre-B cell ...

Disturbed flow generates oscillatory shear stress (OSS), which in turn leads to endothelial inflammation and atherosclerosis. Piezo1, a biomechanical force sensor, plays a crucial role in the ...