The purine/purinergic system has emerged as a fundamental regulator of cellular communication, influencing various physiological processes such as metabolism, energy balance, and signal transduction.

with the consequence of continuous pathophysiological signaling of adipocytes. Figure 2: Inflammatory cells and adipocytes in adipose tissue in obesity. The first report on the infiltration of ...

Hesperetin activated the adipose thermogenic program and facilitated metabolic homeostasis in mice with diet-induced obesity (DIO) dependent on ADGRA3. In the present study, we have elucidated a novel ...

Leptin, primarily produced by adipose tissue, regulates hunger by signaling satiety to the hypothalamus. However, in obesity, leptin's transport to the brain is often blocked, leading to leptin ...

H 2 S generated by adipose tissues regulates the local insulin sensitivity. H 2 S can act as an 'adipocytes-derived relaxing factor' in aortic periadventitial adipose tissues. H 2 S plays ...

The hypothalamus integrates neurohormonal signaling from gut and adipose tissue. Specific hypothalamic nuclei, including the dorsomedial nucleus (DMN), paraventricular nucleus (PVN) and ...

Now, in a new study published in the Journal of the Endocrine Society ... we quantify the underlying pulsatile physiological signaling to enable extending investigations of leptin signaling ...