Scientists engineered T cells to protect instead of kill, potentially enabling targeted treatments for autoimmune disease and ...

为解决 IBD 患者 VTE 发病机制不明的问题，爱尔兰皇家外科医学院的研究人员开展组织因子相关研究。结果发现 CD4+TF+ T 细胞及活化 PC 的调节作用。这为理解 IBD 与 VTE 关系及开发新疗法提供依据，强烈推荐科研读者阅读。

Researchers determine a complex immune infiltrate pattern based on a newly constructed immune map developed using pancreatic ...

Introduction Coeliac disease (CD) is a common immune-mediated condition driven by aberrant adaptive CD4+ T cell responses to gluten ... γδ+ T cells revealed two transcriptionally distinct clusters of ...

We characterize hnRNPC2-controlled IES, which depends on the MEK-ERK pathway and the T cell-specific kinase PKCθ. This splicing switch mainly targets components of the translation machinery, such as ...

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...

Scientists explore how the immune and nervous systems constantly communicate, influencing brain diseases, behavior, and ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.

Perpetuation then results from the effects of these stimuli on maintaining the activated phenotype and generating fibrosis. The earliest changes in stellate cells are likely to result from ...

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

This important study explores the conserved role of IgM in both systemic and mucosal antiviral immunity in teleosts, challenging established views on the differential roles of IgT and IgM. The ...