acetylation and deacetylation of lysines, ubiquitylation of lysines and sumoylation of lysines. Histone modifications are proposed to affect chromosome structure and function, for instance during ...

Mechanisms that have been characterized in SSc include DNA methylation and histone acetylation and deacetylation. Both DNA methyltransferase inhibitors and HDAC inhibitors have been successfully ...

Our results suggest that HDAC6 inhibits cGAS activation through TRIM56 deacetylation in a species-specific manner. TRIM56 K110 acetylation promotes cGAS monoubiquitination and its DNA binding ability.

Department of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia ...

Epigenetic modifications such as DNA methylation and histone acetylation contribute to ... It has been shown that DNA methylation and histone deacetylation at the FLI1gene contribute to the ...

In this useful study, the authors show that N-acetylation of synuclein increases clustering of synaptic vesicles in vitro and that this effect is mediated by enhanced interaction with ...

Epigenetic modifications, such as histone acetylation and methylation, influence the consolidation and retrieval of fear memories, providing potential therapeutic targets for memory modification.

From Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Victoria, Australia (R.H.R.) Division of Endocrinology and Metabolism (E.D.A.), ...

Pancreatic ductal adenocarcinoma (PDAC) constitutes one of the most aggressive malignancies with a 5-year survival rate of <7%. Due to growing incidence, late diagnosis and insufficient treatment ...

Of note, both models clearly indicated decrease in tubulin acetylation as a possible cause of mitochondrial deficits, which were then restored by HDAC6 inhibitors. However, DRG neurons from mice ...

By modulating the interaction of glycoproteins with galectins and other lectins, O-acetylation influences how these glycoproteins cluster and move within the plasma membrane to allow for longer ...