Acamprosate modulates glutamate neurotransmitter pathways through an unknown mechanism to reduce alcohol withdrawal hyperexcitability. Acamprosate has been shown to be beneficial in a subgroup of ...

2012;5(4):427-435. Recent comparisons of naltrexone and acamprosate using systematic literature review conclude that, although both drugs are effective as adjuvant therapies for alcohol dependence ...

Other Drugs Sometimes Used Off-Label for AUDS Although disulfiram, naltrexone, and acamprosate are the only medications approved by the FDA for AUD, other drugs are sometimes prescribed off-label.