Overall, 874 patients underwent randomization, with 331 assigned to imlunestrant, 330 to standard therapy, and 213 to imlunestrant–abemaciclib. Among 256 patients with ESR1 mutations, the median ...

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a T-cell–mediated severe cutaneous adverse reaction characterized by rash, fever, internal organ involvement, and systemic ...

Recognition of autism and autism diagnoses have increased substantially in recent years. But most nonautistic physicians don’t have the skills to effectively engage with autistic people.

Whether surgical axillary staging as part of breast-conserving therapy can be omitted without compromising survival has remained unclear. In this prospective, randomized, noninferiority trial, we ...

Standard treatment for multibacillary leprosy is multidrug therapy consisting of dapsone, rifampicin, and clofazimine, with a recommended treatment duration of 12 months. 4 Challenges include ...

Participants received CD68-ET3-LV–transduced autologous CD34+ HSCs at doses of 5.0×10 6 to 6.1×10 6 per kilogram of body weight. The vector copy numbers in the final drug product were 1.0 and ...

Cell-free DNA (cfDNA) sequence analysis to screen for fetal aneuploidy can incidentally detect maternal cancer. Additional data are needed to identify DNA-sequencing patterns and other biomarkers ...

The effect of a liberal red-cell transfusion strategy as compared with a restrictive strategy in patients during the critical care period after an aneurysmal subarachnoid hemorrhage is unclear.

A blast injury is physical trauma caused by the rapid pressure wave and associated fragments generated by an explosion. 1,2 The resulting blast wave compresses air within open and enclosed spaces ...

Daratumumab, an anti-CD38 monoclonal antibody, has been approved for the treatment of multiple myeloma. Data are needed regarding the use of daratumumab for high-risk smoldering multiple myeloma ...

Dr. Vandana L. Madhavan: A 30-month-old boy was admitted to this hospital for the third time in 4 weeks because of recurrent fever. The patient had been well until 4 weeks before the current ...

The benefit of percutaneous coronary intervention in patients with stable coronary artery disease undergoing transcatheter aortic-valve implantation for severe aortic stenosis has been unclear.