TNFRSF11A encodes the receptor activator of NFκB (RANK), which is critical for normal osteoclast formation; genetic variants in this gene result in familial expansile osteolysis, a Paget-disease ...

The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that regulates both osteoclast and osteoblast differentiation can aid the ...

While several scientific reports have revealed the distinct regulatory mechanisms of osteoclast and osteoblast differentiation, little is known about the common factors that influence the ...

To identify novel bone remodeling factors and related mechanisms involved in both osteoclast and osteoblast differentiation, a team of researchers led by Professor Tomoki Nakashima from the ...