This ongoing study uses minimal residual disease analysis at two follow-up points, to facilitate risk-adapted treatment stratification in ALL patients aged 1–18 years. In the current analysis ...
Increasing evidence exists regarding the involvement of methyltransferase 1, tRNA methylguanosine (METTL1) in cardiac repair and fibrosis. The search for new therapeutic targets for alleviating ...
The AptaFluor SAH Methyltransferase Assay uses a highly sensitive RNA aptamer that is capable of directly detecting SAH. The sensitivity of the aptamer (measures SAH at concentrations below 10 nM ...
The behavior of a person's genes doesn't just depend on the genes' DNA sequence - it's also affected by so-called epigenetic factors. Changes in these factors can play a critical role in disease.
Switzer, R. L., Hartman, Z. J.*, Hewett, G. R.*, and Carroll, C. F.* (2023) “Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1” DNA 3, 119 ...
The dynamic conformational landscape of the protein methyltransferase SETD8. Elife. 2019 May 13;8:e45403. (This work was highlighted by Elife Digest, News of Shanghai Institute of Materia Medica, ...