It is a survival and proliferation factor for a variety of tumor types. EGFR signals through the RAS/RAF/MEK/ERK pathway. Upon activation by extracellular ligands, EGFR dimerizes and ...

The FDA approval of amivantamab-vmjw (Rybrevant) in combination with chemotherapy is the first targeted treatment to cut disease progression risk for EGFR-positive non–small cell lung cancer ...

LACTB是一种哺乳动物蛋白，其结构域序列与青霉素结合蛋白和β-内酰胺酶相似。最近的一项研究表明，在乳腺癌中，LACTB作为肿瘤抑制因子，参与调节脂质代谢。此后，更多学者对LACTB蛋白进行了探索，报道其在乳腺癌、肝细胞癌、结直肠癌、胶质母细胞瘤等多 ...

【导读】尽管存在表皮生长因子受体酪氨酸激酶抑制剂（EGFR-TKI）等靶向治疗，但由于耐药性阻碍了其疗效，非小细胞肺癌（NSCLC）仍然是一个临床挑战。2024年9月25日，中山大学药学院（深圳）陈洪中团队在期刊《Science ...

Mission Statement: Evidence-based Complementary and Alternative Medicine (eCAM) is an international, peer-reviewed journal that seeks to understand the sources and to encourage rigorous research ...

Then, IL-2 signaling is transduced through three distinct pathways: JAK-STAT, MAPK/ERK and PI3K/Akt/mTOR. Recent studies have identified that the IL-2/IL-2R signaling pathway is an essential ...

【导读】LACTB在几种肿瘤中被认为是肿瘤抑制因子。然而，初步研究表明，在骨肉瘤中，LACTB过表达，预示预后不良。 9月26日，中山大学尹军强教授 ...