FMC63, an IgG2a mouse monoclonal antibody, targets CD19. To date, a majority of the reported CART19 trials include the anti-CD19 scFv extracted from FMC63, such as both the FDA-approved CARs ...
Until now, two anti-CD19 CAR-T cell therapies and one bispecific anti-CD19/CD3 antibody have received approval from the FDA for the treatment of hematologic B-cell malignancies. As per ...
Blocking the signalling between CD47 and SIRPα with anti-CD47 mAbs ... the functions of two antibodies, with one light chain binding to CD47 and the other to CD19. The CD47-binding domain has ...
Tafasitamab binds to CD19, a protein on the surface of B-cells that is also targeted by Amgen’s bispecific antibody Blincyto (blinatumomab) for acute lymphoblastic leukaemia (ALL), as well as tw ...
Clinical Trials of ADCs for the Treatment of B-cell Malignancies Five ADCs targeting the B-lineage antigens CD22, CD19 and CD70 are ... single-agent IO demonstrated anti-tumor activity in relapsed ...
Other potential treatments for NMOSD are also coming through the industry pipeline, including Viela Bio’s anti-CD19 antibody inebilizumab, which completed a first phase 3 trial earlier this year ...