We know today that Wnt ... Wnt pathway are linked to human diseases other than cancer (reviewed in Refs 141, 218): Loss-of-function mutations of LRP5 are not only linked to low bone mass but ...

Cite this: Bone Signaling Pathways and Treatment of Osteoporosis ... osteoclast activity and survival. Canonical Wnt signaling regulates bone formation and is essential for osteoblast ...

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Canonical Wnt signaling regulates bone formation and is essential for ... antibodies to Dkk1 and sclerostin. Novel regulatory pathways linking fat mass, the CNS and the GI tract to the control ...

Despite diverse post-systematic evolution of ligands by exponential enrichment (post-SELEX) modifications explored in aptamer optimization, accurate prediction of high-affinity modification strategies ...

Bone changes were evaluated by micro-CT imaging. Topical C59 delivery led to a dose-dependent reduction in endogenous Wnt signaling ... depend on restoring Wnt pathway activity to maintain ...

"In fact, a new drug, vosoritide, has recently been developed that acts on the cGMP signaling pathway in bone and is used to treat dwarfism in children. The parallels that our study has shown ...