Disruptions in the dynamic balance of D1-receptor mediated phosphorylation and dephosphorylation cascades in different regions of the neuron may lead to impaired integration of synaptic inputs.

CDK2–cyclin A, CDK2–cyclin E, CDK4–cyclin D1, CDK5–p35, His-tagged Erk1 and Erk2, protein kinase C isoforms, the catalytic subunit of cAPK, cGMP-dependent protein kinase, casein kinases 1 ...

引言尿路上皮癌（UC）是一种常见且致命的癌症，具有显著的遗传异质性【1】。在癌症发展过程中，突变过程和DNA修复之间不断相互作用，导致产生独特的突变特征和广泛的基因组结构变化。APOBEC3家族的胞嘧啶脱氨酶可在多种人类癌症的基因组中引起胞嘧啶向胸腺 ...

摘要： 癌细胞对化疗药物的耐药性大大降低了癌症患者的治疗效果，化疗引起的毒副作用也严重影响了患者的生活质量。茶中主要活性成分表没食子儿茶素-3-没食子酸酯（EGCG）与顺铂、5-FU、多柔比星和紫杉醇的联合使用，增强了它们对肿瘤的增敏效果，并对抗了癌细胞的耐药性。这些效应似乎通过多种机制介导，包括对抗癌症干细胞介导的药物耐药性、增强药物敏感性、诱导细胞周期停滞和凋亡，以及阻断血管生成。此外，EGC ...

His current work focuses on the role of E3 ubiquitin ligases in the maintenance of cyclin D1 levels and the physiological function of the E3 ligase in tumor suppression. Additional work focuses on the ...

If you’re wondering what an IMEI number is, you’ve come to the right place. You’ve probably heard the acronym at carrier stores, during tech support calls, or whenever you need to switch ...

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Steam has been a big name in the gaming world for a while now. If you own a Steam Deck or a gaming PC, you’ll definitely know this, but what is Steam, and how does it work? We’ll explain the ...

Opinions expressed by Forbes Contributors are their own. Senior Editor for CryptoSlate and host of the Slatecast podcast. Ethereum is a decentralized platform enabling the creation of ...

The climate has changed naturally throughout the Earth's history. But natural causes cannot explain the particularly rapid warming over the last century, according to the UN's climate body, the ...

A focus group is reviewing a new product and none of them believe it works. When asked for a testimonial, many in the group say the product is excellent.

We define corruption as the abuse of entrusted power for private gain. Corruption erodes trust, weakens democracy, hampers economic development and further exacerbates inequality, poverty, social ...