The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab ... We are also actively investigating the ...

The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?

Aberrant activation of the Src family of tyrosine kinases has been implicated in ... of combination therapy with epidermal growth factor receptor inhibition and cytotoxic chemotherapy.

AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central ...