Vinculin is important in the maintenance and regulation of cell adhesion and migration, and it adopts an autoinhibited conformation in the cytosol. It becomes activated on recruitment to cell ...

Cryo-electron microscopy reconstructions of the cell adhesion proteins vinculin (left, orange) and a-catenin (right, pink) bound to actin filaments (blue). Advanced Search Home ...

The detailed sequence of events following ECM binding to the integrin is not known, but the β-subunit cytoplasmic domain interacts directly with talin, and talin interacts with both vinculin and ...

Ezutromid was designed to treat DMD by boosting utrophin levels to compensate for the faulty dystrophin protein that is the root cause of the very rare muscle-wasting disease. Summit reported ...

For innovation in medicinal chemistry leading to the identification of first in class utrophin modulators for the treatment of Duchenne muscular dystrophy. Throughout this endeavour has been, and ...

Michael Boyle is an experienced financial professional with more than 10 years working with financial planning, derivatives, equities, fixed income, project management, and analytics. Suzanne is a ...

Immunotherapy Guided by Immunohistochemistry PD-L1 Testing for Patients with NSCLC: A Microsimulation Model-Based Effectiveness and Cost-Effectiveness Analysis. Ixekizumab for Active Radiographic ...

The classic sausage and mash served with homemade onion gravy and peas. Simple and sure to please all the family. This is designed to be a low cost recipe. Preheat the oven to 200C/180C Fan/Gas 6 ...

When we write a sentence we always use a capital letter at the start and punctuation at the end (usually a full stop). For example: This is an example of how to use capital letters and full stops ...

Vikki Velasquez is a researcher and writer who has managed, coordinated, and directed various community and nonprofit organizations. She has conducted in-depth research on social and economic ...

Two contestants pit their linguistic and numerical skills against each other and the clock in this entertaining quiz show. Two contestants pit their linguistic and numerical skills against each ...