High uric acid levels can lead to formation of crystals leading to inflammation. Here is how it may affect your kidney too.

However, these data suggest that there may be some abnormality in uric acid metabolism in the heterozygote, but that it is not regularly possible to detect the presence of the abnormal gene by ...

"Our findings indicate that serum and CSF uric acid levels are not directly related to upstream xanthine concentrations, suggesting influences beyond traditional purine metabolism pathways." ...