通过线粒体转移，癌细胞不仅实现了对T细胞功能的精确抑制，还为其免疫逃逸增加了一道屏障。该研究进一步指出，这种机制与免疫治疗效果不佳密切相关，尤其是在携带大量mtDNA突变的患者中，免疫检查点抑制剂的疗效显著降低。

The following is a summary of “Introducing Neoadjuvant Immunotherapy for Colorectal Cancer: Advancing the Frontier,” ...

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Zai Lab Limited (ZLAB) announced that the U.S. Food and Drug Administration has granted Orphan Drug Designation or ODD to ZL-1310, a ...