HIF1α identified as key regulator that induces cancer-killing ability of hypoxic T cells, playing a role in ICB resistance.

The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen, and it may be involved in resistance to immune checkpoint blockade therapy. In a study published in Nature Communications, ...

Study uncovers how Cancer-associated Fibroblasts influence tumour immunity, paving the way for targeted cancer treatments.

The study explored the complex interactions between tumor cells and immune cells, including T cells, M1/M2 macrophages, and their localized impact on the tumor microenvironment, offering insights ...

Foundery Immune Studio, LLC, a biotechnology venture studio focused on translating immunology discoveries into medicines, ...

exerts dual effects on the tumor microenvironment (TME), necessitating integration with systemic therapies like immune checkpoint inhibitors (ICIs). Yet, therapeutic resistance, hypoxia-induced ...

Immune checkpoint blockades ... potential intervention has to take place under unusual conditions -- the cancer microenvironment nearly devoid of oxygen due to fast growth of a tumor and the ...

Solnerstotug (SNS-101) dose expansion arm anticipated to be fully enrolled by end of Q1 2025 -- Clinical data update expected in Q2 2025 - ...

Deciphering craniopharyngioma subtypes: Single-cell analysis of tumor microenvironment and immune networks. iScience , 2024; 27 (11): 111068 DOI: 10.1016/j.isci.2024.111068 Cite This Page : ...

Craniopharyngiomas are brain tumors that negatively impact the hormonal function of the nearby pituitary. The tumor location often prevents necessary surgical intervention. Alternative ...