TREX1 is an enzyme that degrades cytosolic DNA (a danger signal) and prevents it from binding to cyclic GMP–AMP synthase (cGAS) and activating the STING pathway. Mutations in TREX1 cause ...
cGAS titration at 1 hour and 24 hours demonstrates the assay's oustanding signal stability. The signal stability seen here is crucial for HTS where the screen size can require significant more time.