Meier and coauthors found that topotecan improved progression-free and overall survival compared with treosulfan in patients with recurrent ovarian cancer following platinum and taxane-based therapy.

Researchers from IACS Kolkata have identified TDP1 as a potential target for cancer therapy, offering hope for overcoming ...

Patients who have relapsed or individuals who do not respond to first-line chemotherapy can be treated with topotecan. Phase II and III studies have confirmed the efficacy of topotecan as second ...

In a promising development for cancer treatment, researchers have pinpointed a new target by activating a DNA repair enzyme ...

Ticiana Leal, MD, discusses how in cases of extensive stage small cell lung cancer (ES-SCLC) that progress within 6 months of ...

MIRASOL is a global phase 3 open-label, randomized, controlled trial that enrolled 453 patients to compare the efficacy and safety of mirvetuximab soravtansine with the investigator's choice of single ...

A Randomized Trial of Cisplatin With or Without Topotecan in Advanced Carcinoma of the Cervix GOG 204 (pending publication) A Randomized Trial of Paclitaxel Plus Cisplatin Versus Vinorelbine Plus ...

Background: Variable rates of HER2 protein overexpression and gene amplification have been reported in advanced ovarian cancers (AOC). Trastuzumab, tested only as a single agent, has been shown to ...

Treatment with cediranib or cediranib plus olaparib is not superior to standard of care (SOC) in patients with platinum-resistant or -refractory epithelial ovarian cancer, according to results from a ...