来自MSN4 个月
Distinct T-cell signatures observed at different stages of type 1 diabetes development
an increased frequency of T cells expressing the co-inhibitory receptors KLRG1 and TIGIT was detected. Importantly, the latter signature resembles the CD8 + T-cell signature associated with a ...
腾讯网21 天
中南大学湘雅二医院团队发现1型糖尿病进展与缓解的新机制
总之，这些发现揭示了一个先前未知的免疫细胞新亚群的动态相互作用，即tigit+treg-tgf-β-cd226+cd8+t，该作用轴不仅调控免疫环境的稳态，还为t1d提供 ...
pharmaphorum2 天
Roche nabs breakthrough tag for TIGIT cancer immunotherapy
Like PD-L1, TIGIT is thought to act as a molecular brake that stops T cells from attacking tumours, and tiragolumab is currently leading the pack among drugs targeting the immune checkpoint.
pharmaphorum1 年
Roche hit by failure of TIGIT drug tiragolumab in lung cancer
Like PD-L1, TIGIT is thought to act as a molecular brake that stops T cells from attacking tumours, and tiragolumab is currently leading the pack among drugs targeting the immune checkpoint.