The evidence supporting the relevance of replicative senescence of human cells and telomere biology to human cancer is now quite strong. The evidence linking replicative senescence to human aging ...

Protection of this overhang is essential. When left unprotected, this overhang initiates DNA damage responses that lead to catastrophic events permanently damaging the genome and resulting in ...

Researchers at The University of Texas MD Anderson Cancer Center have identified a potential breakthrough in the fight ...

Replicative senescence is associated with telomere shortening and the loss from the ends of chromosomes of about 100 bp per population doubling. In March 19 Science, Jan Karlseder and colleagues at ...

The researchers found that when APCSs deliver their telomeres to T cells, the latter shift into stem cell-like configuration, which delays their senescence. The researchers also found that this ...

With each cell division, telomeres shorten until they reach a certain critical length, which causes cells to undergo senescence (cell cycle arrest). In the presence of viral oncogenes or somatic ...

Over time, these caps shorten, eventually reaching a point where cells can no longer divide, leading to senescence or cell death. Shortened telomeres have been linked to various age-related ...

These findings indicate that telomere length is not directly correlated with evasion of senescence or tumorigenesis, and that telomerase might have some other protumorigenic functions.

This was the first link between the molecular biology of telomeres and cellular senescence, the aging and death of cells. Since Szostak’s, Blackburn’s, and Greider’s early work on telomerase, ...

For my postdoctoral work at the University of Sheffield (UK), Molecular Ecology, I have studied senescence and telomere biology in an insular island population of wild house sparrows. The current ...