Tay-Sachs disease is a rare hereditary disorder that ... for individuals in high-risk groups like Ashkenazi Jewish people, ...

What Is Tay-Sachs Disease? A baby with Tay-Sachs disease is born without an important enzyme. Enzymes are proteins that control chemical reactions in the body. Without this enzyme, called ...

Carrying Tay-Sachs disease may protect against tuberculosis (TB). In Ashkenazim populations, up to 11 percent of the people are Tay-Sachs carriers. During World War II, TB ran rampant in Eastern ...

As young people in the community were tested ... Niemann–Pick disease and Canavan disease. Those illnesses, like Tay-Sachs, will only manifest if both parents carry the same defective gene.

Tay-Sachs disease (TSD) is a type 1 gangliosidosis (GM2) and caused by hexosaminidase A deficiency resulting in abnormal sphingolipid metabolism and deposition of precursors in different organs. It is ...

Late-onset Tay-Sachs disease/GM2-gangliosidosis can occur without any considerable psychiatric symptoms and outside Jewish populations.

In one particular variant of this disease known as mucopolysaccharidosis I (MPS I), a deficiency of the enzyme alpha-L-iduronidase causes a build up of GAGs in tissues and organs, which in turn ...

Currently there is no cure for Tay-Sachs disease. Only palliative care is available. If successful, our therapeutic candidate will restore beta-hexosaminidase activity in the CNS of affected patients ...

By examining cells from your placenta, called chorionic villi, through a biopsy, we can determine if your baby has genetic conditions that run in families, such as Tay-Sachs disease or hemophilia, and ...