Tay-Sachs disease is a rare hereditary disorder that ... for individuals in high-risk groups like Ashkenazi Jewish people, ...

Carrying Tay-Sachs disease may protect against tuberculosis (TB). In Ashkenazim populations, up to 11 percent of the people are Tay-Sachs carriers. During World War II, TB ran rampant in Eastern ...

In one particular variant of this disease known as mucopolysaccharidosis I (MPS I), a deficiency of the enzyme alpha-L-iduronidase causes a build up of GAGs in tissues and organs, which in turn ...

As young people in the community were tested ... Niemann–Pick disease and Canavan disease. Those illnesses, like Tay-Sachs, will only manifest if both parents carry the same defective gene.