Recent studies implicate the immune system and a herpes virus as potential contributors to development of disease ...

Nevertheless, the hypothesis still dominates research and drug development ... This line of inquiry follows animal model and stem cell studies in which efavirenz reduced the accumulation of both ...

The clumping of amyloid beta in the brain to form plaques is one the hallmarks of AD, and the 'amyloid hypothesis' suggests they are a primary driver for the neurodegeneration seen in the disease.

The revised criteria offer guidance for clinicians to determine when amyloid and tau PET are recommended. Criteria were divided into 17 common clinical scenarios with three subcategories of ...

One leading hypothesis suggests that amyloid-beta triggers hyperactivity in brain cells, which exacerbates tau pathology and leads to progressively slower brain activity as the disease advances.

The cascade component of the hypothesis captures the idea that the production of Aβ not only leads to amyloid plaques, but also has other downstream effects including hyperphosphorylation of tau ...

There's still so much we don't know about Alzheimer's disease, but the link between poor sleep and worsening disease is one ...

along with amyloid plaques. AC Immune has a lot riding on the tau hypothesis. Along with semorinemab, the biotech has also partnered with Johnson & Johnson on a tau-targeting vaccine (ACI-35 ...

Elucidation of part of the Mechanism by which Lecanemab Slows the Progression of Alzheimer's Disease ...