Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...
Biological processes are precisely regulated by TFs, miRNAs and other regulators. We aim to combine data from different sources, e.g, TF binding data (ChIP-seq and ChIP-chip), gene expression data ...
A new study has explored the RNA-binding mechanisms of the antiviral protein TRIM25. TRIM25 (green, left) finds its way to the same locations in the cell where a virus (red, middle) replicates.
TRIM25 is a protein that is important in the innate immune response against RNA viruses, such as influenza viruses, coronaviruses, or Zika virus. New research has shown how TRIM25 binds to viral ...
This work presents a valuable finding on how the interplay between transcription factors SOX2 and OCT4 establishes the pluripotency network in early mouse embryos. Despite the high quality of the data ...
There are 12 members of the SR protein family. This family of RNA-binding proteins is most known for RNA splicing. SRSF1 oversees the splicing of more than 1,500 different messenger RNA transcripts.