A key element of the T synapse is the specific relationship between the ring of integrin adhesion molecules and the central cluster of TCRs 3. (The location of adhesion molecules in the B cell ...

We show here active clustering of TCR–MHC molecules at the immune synapse after interaction between aAPC and T cells. This multivalent system allows identification and stimulation of antigen ...

Dr. Roddy O'Connor explores "hit & run" serial killing in CAR T cells, discussing how metabolic reprogramming influences ...

Ahmed Gad, postdoctoral associate in Ahmed’s lab, the research team examined molecular dynamics at the immune synapse. The team biopsied the CAR T cell immunological synapse by isolating the mem ...