An international research team has uncovered a new mechanism crucial to the production of cellular proteins. When this ...

Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell.

New work suggests that Prp8, a highly conserved protein in the heart of the spliceosome, both orients the substrate and participates in catalysis. The U5 snRNP functions in spliceosome assembly as ...

Is this a glimpse of the spliceosome's catalytic core? Identifying divalent metal ion binding sites in RNA molecules is a formidable task, especially when the RNAs reside within large, dynamic ...

The spliceosome edits genetic messages transcribed from DNA, allowing cells to create different versions of a protein from a single gene. The vast majority of human genes -- more than nine in ten ...

西班牙基因组调控中心的科学家们近日首次绘制出人类剪接体（spliceosome）的图谱，这是每个细胞中最复杂的分子机器。这项工作耗费十多年时间才完成，研究成果于2024年10月31日发表在《Science》杂志上。 西班牙基因组调控中心的科学家们近日首次绘制出人类 ...

Researchers at the Centre for Genomic Regulation (CRG) have created the first blueprint of the human spliceosome, the complex molecular machine that edits genetic messages transcribed from DNA ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona, a BIST Community centre, have created the first blueprint of the human spliceosome, the most complex and intricate molecular ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell.

This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...