Cirrhosis leads to an elevation in intrahepatic vascular resistance. Splanchnic vasodilation increases the production of vasodilators (nitric oxide, carbon monoxide, prostacyclins and ...

NO. NO plays a central role in the pathophysiology of systemic and splanchnic vasodilation in cirrhosis. NO is synthesized from L-arginine by the action of NO synthase (NOS), which exists in three ...