Most experts, however, say it's too soon to write off Sirtris' compounds altogether, assuming they're clinically useful by mechanisms that don't involve sirtuin binding. And for its part ...

The researchers took an unbiased approach, comparative metabolomics, a methodology developed by the Schroeder lab for over a decade, to screen for sirtuin-dependent metabolic changes. The study ...

He also studies what happens when these processes break down. Second, Dr. Bedalov is developing potential cancer drugs called sirtuin inhibitors that affect a cell process for regulating gene ...