Gross pathological findings were not remarkable; no notable macroscopic lesions were observed in the brain of any animal. Protocol-required tissues and ... high-dose female rat had a large focus ...

Tg12099; Mapt-/-rats developed tau pathology—including neurofibrillary tangles—and exhibited similar patterns of brain atrophy as Tg12099 homozygotes expressing rat tau. Initial studies with Tg12099 ...

University of Wisconsin–Madison researchers targeting a group of hereditary neurodegenerative diseases have found success ...