A shared interest in the biology of aging brought a chemist, a geneticist and a biologist together to found Proteostasis Therapeutics. In 2006, chemist Jeffery Kelly from The Scripps Research ...

This mechanism regulates proteostasis across tissues by modulating TGF-β signaling, a pathway involved in cell growth, differentiation, and tissue homeostasis. This breakthrough opens exciting ...

A new study reveals that Mitofusin 2 (MFN2) plays a crucial role in protein quality control, preventing harmful protein ...

We aim to define molecular functions of cellular factors that facilitate protein homeostasis within the endoplasmic reticulum as well as to uncover small molecules that modulate proteostasis as ...

A common theme in neurodegenerative diseases is a defective proteome due to dysregulation of proteostasis, a key system that ensures all proteins within a cell are synthesized, folded, trafficked ...

Nobel Laureate Prof. Aaron Ciechanover (2004, Chemistry) delivered a special address at the inaugural of ProUPS (Proteostasis ...